YM-202074 is a selective allosteric antagonist of metabotropic glutamate receptor type 1 (mGluR1) with significant affinity, exhibiting a Ki value of 4.8 nM for rat mGluR1. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, with an IC50 of 8.6 nM. Additionally, YM-202074 demonstrates potent neuroprotective effects in transient middle cerebral artery occlusion rat models, making it a valuable tool for research in neuroprotection and glutamatergic signaling pathways.
YM-202074 is a selective allosteric antagonist of metabotropic glutamate receptor type 1 (mGluR1) with significant affinity, exhibiting a Ki value of 4.8 nM for rat mGluR1. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, with an IC50 of 8.6 nM. Additionally, YM-202074 demonstrates potent neuroprotective effects in transient middle cerebral artery occlusion rat models, making it a valuable tool for research in neuroprotection and glutamatergic signaling pathways.
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