Fig. 1 · Structure
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YM-202074
mGluR1 Antagonist
YM-202074 is a selective allosteric antagonist of metabotropic glutamate receptor type 1 (mGluR1) with significant affinity, exhibiting a Ki value of 4.8 nM for rat mGluR1. This compound effectively inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells, with an IC50 of 8.6 nM. Additionally, YM-202074 demonstrates potent neuroprotective effects in transient middle cerebral artery occlusion rat models, making it a valuable tool for research in neuroprotection and glutamatergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 299900-83-7 |
| Applications | mGluR1 Antagonist |
| Formula | C22H30N4O2S |
| Molecular Weight | 414.56 |
| SMILES | O=C(N(C1CCCCC1)C)C2=CN3C4=C(C=CC(CN(CCOC)C)=C4)N=C3S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.