Fig. 1 · Structure
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YM-230888
mGlu1 Receptor Antagonist
YM-230888 is a selective allosteric antagonist of the metabotropic glutamate receptor 1 (mGlu1), exhibiting a binding affinity (Ki) of 13 nM. It effectively inhibits the production of inositol phosphates in rat cerebellar granule cells, with an IC50 of 13 nM. Research indicates that YM-230888 possesses significant antinociceptive effects in models of hyperalgesia induced by Streptozotocin, as well as in complete Freund's adjuvant-induced arthritis pain models, highlighting its potential utility in pain management studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 446257-23-4 |
| Applications | mGlu1 Receptor Antagonist |
| Formula | C19H28N4OS |
| Molecular Weight | 360.52 |
| SMILES | C1(NC2CCCCCC2)=C3C(SC(CNC[C@H]4CCCO4)=C3)=NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.