Fig. 1 · Structure
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YM-60828 methanesulfonate
FXa Inhibitor
YM-60828 methanesulfonate is a selective inhibitor of factor Xa (FXa) that exhibits significant antithrombotic properties. In preclinical studies using a rat arteriovenous shunt model, YM-60828 effectively reduces levels of thrombin-antithrombin III complex (TAT) in a dose-dependent manner without prolonging coagulation time. Its specific action on FXa, rather than thrombin, highlights its potential for therapeutic applications aimed at managing thrombotic disorders while allowing for TAT monitoring as a measure of its antithrombotic effect.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 209187-02-0 |
| Applications | FXa Inhibitor |
| Formula | C28H35N5O8S2 |
| Molecular Weight | 633.74 |
| SMILES | O=S(N(CC1=CC=C2C=CC(C(N)=N)=CC2=C1)C(C=C3)=CC=C3OC4CCN(CC4)C(C)=N)(CC(O)=O)=O.O=S(O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.