YM114 is a highly selective antagonist of the 5-HT3 receptor, demonstrating notable potency in inhibiting receptor activity. It has been shown to disrupt the Bezold-Jarisch reflex induced by 2-methyl-5-HT without affecting bradycardia resulting from Veratridine or electrical stimulation in anesthetized rats. This compound offers valuable insights into cardiovascular and neuropharmacological research applications, particularly in understanding the role of 5-HT3 receptors in vagal afferent nerve signaling.
YM114 is a highly selective antagonist of the 5-HT3 receptor, demonstrating notable potency in inhibiting receptor activity. It has been shown to disrupt the Bezold-Jarisch reflex induced by 2-methyl-5-HT without affecting bradycardia resulting from Veratridine or electrical stimulation in anesthetized rats. This compound offers valuable insights into cardiovascular and neuropharmacological research applications, particularly in understanding the role of 5-HT3 receptors in vagal afferent nerve signaling.
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