YM155 (Sepantronium Bromide)

YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
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Product Name Price Stock Qty
YM155 5mg
$40.00
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YM155 10mg
$70.00
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YM155 25mg
$150.00
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YM155 100mg
$400.00
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YM155 10mM * 1mL in DMSO
$50.00
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Adooq Products cited in reputable paper
Adooq's YM155 (Sepantronium Bromide) has been cited by 11 publications
  • Ali Nasrollahzadeh, .et al. , Biochim Biophys Acta Mol Cell Res, 2021, Jun 26;1868(10):119087 PMID: 34182011
  • Chia-Hui Huang, .et al. , Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283
  • Turner TH, .et al. , Sci Rep, 2020, Jan 30;10(1):1493 PMID: 32001757
  • Chiou JT, .et al. , Toxicol Appl Pharmacol, 2019, Dec 16;387:114857 PMID: 31837377
  • Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Momeny M, .et al. , Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
  • Yamamoto M, .et al. , Anticancer Res, 2019, Feb;39(2):609-617 PMID: 30711936
  • Vázquez-Mellado MJ, .et al. , Oncol Rep, 2018, Nov 27 PMID: 30483799
  • MASAHIRO YAMAMOTO, .et al. , Anticancer Res, 2018, Dec 38 (12) 6699-6706 PMID: 30504379
  • Ahn MR, .et al. , Drug Discov Ther, 2017, 11(6):300-306 PMID: 29332887
  • MASAYA MINODA, .et al. , Int J Oncol, 2015, Sep; 47(3): 891-899 PMID: 26166250
  • Biological Activity
    Discription YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
    Targets
    Target Value
    Product Information
    Catalog Num A11002
    Formula C20H19BrN4O3
    Molecular Weight 443.3
    CAS Number 781661-94-7
    SMILES CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 52 mg/mL (117.3 mM)
    Water 85 mg/mL (191.75 mM)
    Ethanol 6 mg/mL (13.53 mM)
    In vivo Saline 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.56 mL 112.79 mL 225.58 mL
    0.5 mM 4.51 mL 22.56 mL 45.12 mL
    1 mM 2.26 mL 11.28 mL 22.56 mL
    5 mM 0.45 mL 2.26 mL 4.51 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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