Fig. 1 · Structure
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YM511
Aromatase Inhibitor
YM511 is a highly specific non-steroidal aromatase inhibitor that exhibits competitive inhibition of aromatase activity in microsomes derived from rat ovaries and human placentas, with IC50 values of 0.4 nM and 0.12 nM, respectively. This compound demonstrates minimal inhibition of the production of other steroid hormones, making it suitable for research focused on estrogen-dependent actions. YM511's unique profile supports its potential application in studies investigating the modulation of estrogen without significant alterations in steroid hormone serum levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 148869-05-0 |
| Applications | Aromatase Inhibitor |
| Formula | C16H12BrN5 |
| Molecular Weight | 354.20 |
| SMILES | BrC(C=C1)=CC=C1CN(N2C=NN=C2)C3=CC=C(C#N)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.