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YN14 (mixture of diastereomers)

YN14 Mixture of Diastereomers

YN14 is a mixture of diastereomers that functions as a proteolysis targeting chimera (PROTAC) specifically targeting KRASG12C. This compound exhibits high potency and selectivity in degrading KRASG12C by forming a stable ternary complex with VHL, characterized by low binding free energy (ΔG). YN14 demonstrates significant antiproliferative activity, effectively inhibiting the growth of KRASG12C-mutant cancer cells, making it a valuable tool for cancer research and drug development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3053689-54-3
Applications	YN14 Mixture of Diastereomers
Formula	C₆₂H₇₅F₂N₁₁O₇S
Molecular Weight	1156.39
SMILES	O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4F)OCC5CCN(CC5)CCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)=C(F)C=C3C(N9[C@H](CN(CC9)C(C=C)=O)C)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.