Fig. 1 · Structure
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YTHDC1-IN-1
YTHDC1 Inhibitor
YTHDC1-IN-1 is a selective inhibitor of the YTHDC1 protein, exhibiting a Kd value of 49 nM and an IC50 of 0.35 μM. This compound has been shown to inhibit the proliferation of acute myeloid leukemia cell lines and can induce apoptosis, indicating its potential as a therapeutic agent in cancer research. YTHDC1-IN-1 demonstrates significant anti-tumor activity, making it a valuable tool for studies on leukemia and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2995344-53-9 |
| Applications | YTHDC1 Inhibitor |
| Formula | C13H11Cl2N5 |
| Molecular Weight | 308.17 |
| SMILES | CNC1=NC(Cl)=NC2=C(CC3=CC=CC(Cl)=C3)NN=C21 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.