Fig. 1 · Structure
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YTR107
Radiation Sensitizer
YTR107 is a radiation sensitizer that targets nucleophosmin1 (NPM1) to inhibit its pentamer formation. By preventing the recruitment of nucleophosmin to DNA damage sites, YTR107 suppresses the repair of DNA double strand breaks, thereby enhancing radiosensitization. This compound is useful in investigating the interplay between DNA repair mechanisms and radiation therapy, offering potential insights for cancer treatment strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1207615-74-4 |
| Applications | Radiation Sensitizer |
| Formula | C21H14N4O3 |
| Molecular Weight | 370.36 |
| SMILES | N#CC1=CC=C(CN2C=C(/C=C(C(N3)=O)\C(NC3=O)=O)C4=C2C=CC=C4)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.