Fig. 1 · Structure
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Yuanhuacine
DNA-Damaging Agent
Yuanhuacine, a diterpene derived from Daphne genkwa, acts as a DNA-damaging agent with notable efficacy against the basal-like 2 (BL2) subtype of triple-negative breast cancer (TNBC). This compound induces G2/M cell cycle arrest, demonstrating significant anti-tumor activity. Yuanhuacine is characterized by its oral bioavailability, making it a valuable tool for research in cancer therapies and cellular response to DNA damage.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 60195-70-2 |
| Applications | DNA-Damaging Agent |
| Formula | C37H44O10 |
| Molecular Weight | 648.74 |
| Synonyms | Gnidilatidin |
| SMILES | O=C1C(C)=C[C@]2([H])[C@]1(O)[C@H](O)[C@]3(CO)[C@@]([C@]4([H])[C@]25[C@H](C)[C@@H](OC(C6=CC=CC=C6)=O)[C@@]7(C(C)=C)[C@]4([H])O[C@](O5)(/C=C/C=C/CCCCC)O7)([H])O3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.