Fig. 1 · Structure
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YY173
CDK4/6 Inhibitor
YY173 is a selective dual inhibitor of CDK4 and CDK6, demonstrating IC50 values of 7.7 nM and 88 nM, respectively. This compound effectively inhibits the proliferation of Jurkat cells with an IC50 of 1.46 μM. YY173 serves as a valuable tool for research in cancer biology and is suitable for the synthesis of PROTAC CDK4/6 degrader 1, facilitating studies on targeted protein degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 330550-51-1 |
| Applications | CDK4/6 Inhibitor |
| Formula | C21H25N7O |
| Molecular Weight | 391.47 |
| SMILES | O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.