Fig. 1 · Structure
Documents & Downloads
Z-3578
MrgX2 Antagonist
Z-3578 is an orally active small-molecule antagonist of the MrgX2 receptor, demonstrating potent antipseudoallergic effects with a KD value of 729 nM. This compound effectively inhibits mast cell degranulation triggered by substances such as substance P and C48/80, leading to reduced release of β-hexosaminidase, histamine, and TNF-α, while also decreasing intracellular calcium flux. In murine models of pseudoallergy, Z-3578 has been shown to significantly diminish paw swelling, dye extravasation, and serum histamine levels, making it suitable for research into pseudoallergic reactions.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 473687-20-6 |
| Applications | MrgX2 Antagonist |
| Formula | C23H16Cl2N4OS |
| Molecular Weight | 467.37 |
| SMILES | O=C(CSC1=NC(C2=CC=CC=C2)=C(N=N1)C3=CC=CC=C3)NC4=C(C=C(C=C4)Cl)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.