Fig. 1 · Structure
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Z-Phe-Ala-diazomethylketone
Aβ42 Formation Inhibitor
Z-Phe-Ala-diazomethylketone is an Aβ42 formation inhibitor that targets Aβ42 monomers and small oligomers. This compound effectively inhibits the aggregation of Aβ42 into dodecamers and prevents fibril formation in solution. It holds promise for research in neurodegenerative disorders, providing a valuable tool for investigating the pathogenesis of conditions such as Alzheimer's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 71732-53-1 |
| Applications | Aβ42 Formation Inhibitor |
| Formula | C21H22N4O4 |
| Molecular Weight | 394.42 |
| Synonyms | PADK |
| SMILES | [C@@H](C(N[C@H](C(C=[N+]=[N-])=O)C)=O)(CC1=CC=CC=C1)NC(OCC2=CC=CC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.