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(Z)-Rilpivirine

(Z)-isomer of Rilpivirine

(Z)-Rilpivirine is the (Z)-isomer of Rilpivirine, a potent diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). This compound demonstrates significant antiviral activity against both wild-type HIV, with an EC50 of 0.4 nM, and various mutant strains, exhibiting EC50 values ranging from 0.1 to 2.0 nM. (Z)-Rilpivirine is primarily utilized in research focused on HIV pathogenesis and the development of antiviral therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	500287-94-5
Applications	(Z)-isomer of Rilpivirine
Formula	C₂₂H₁₈N₆
Molecular Weight	366.42
Synonyms	(Z)-R278474; (Z)-TMC278; (Z)-DB08864
SMILES	CC(C=C(C=C1C)/C=C\C#N)=C1NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.