Fig. 1 · Structure
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(Z)-Tyrphostin A51
PTK Inhibitor
(Z)-Tyrphostin A51 is a potent inhibitor of protein tyrosine kinases (PTKs). This compound effectively inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner and significantly reduces cellular tyrosyl phosphorylation levels. Additionally, (Z)-Tyrphostin A51 has been shown to inhibit both basal and EGF-induced proliferation of human bone cells, making it a valuable tool for research into cellular signaling and growth regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 122520-90-5 |
| Applications | PTK Inhibitor |
| Formula | C13H8N4O3 |
| Molecular Weight | 268.23 |
| Synonyms | (Z)-AG-183 |
| SMILES | N#C/C(C#N)=C(N)/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.