Fig. 1 · Structure
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Z218484536
PSPH Inhibitor
Z218484536 is a selective phosphoserine phosphatase (PSPH) inhibitor that effectively penetrates the blood-brain barrier. With a Kd value of approximately 0.23 μM, it demonstrates significant reduction in L-serine and D-serine levels in astrocytes. This compound has shown promise in suppressing spontaneous epileptic seizures and exhibits favorable anti-epileptic effects in temporal lobe epilepsy models, making it a valuable tool for neurological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1223877-07-3 |
| Applications | PSPH Inhibitor |
| Formula | C11H10FN5O |
| Molecular Weight | 247.23 |
| SMILES | O=C(N/N=C/C1=CNN=C1C2=CC=C(F)C=C2)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.