Fig. 1 · Structure
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Z57346765
PGK1 Inhibitor
Z57346765 is a selective inhibitor of phosphoglycerate kinase 1 (PGK1) that binds to the ADP-binding pocket, exhibiting a Kd of 20.9 μM for human PGK1. This compound demonstrates significant anticancer activity by impairing PGK1's function in glycolysis, leading to reduced cancer cell proliferation and increased lipid peroxidation, particularly in cervical cancer cells. Z57346765 is valuable in preclinical studies focused on cervical cancer, clear cell renal cell carcinoma, and breast cancer, where it influences gene expression related to metabolism, DNA replication, and the cell cycle.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1016340-64-9 |
| Applications | PGK1 Inhibitor |
| Formula | C17H18N4O |
| Molecular Weight | 294.36 |
| SMILES | OCCNC1=C2C=CC=CC2=NC(NC3=CC=C(C)C=C3)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.