Fig. 1 · Structure
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ZAP-180013
ZAP-70 Inhibitor
ZAP-180013 is a selective inhibitor of zeta-chain-associated protein kinase 70 (ZAP-70) with an IC50 of 1.8 μM. This compound disrupts the interaction between the SH2 domain of ZAP-70 and immunoreceptor tyrosine-based activation motifs (ITAMs), thereby modulating T cell receptor signaling. ZAP-180013 is valuable in research applications focused on understanding immune responses and T cell activation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 873080-25-2 |
| Applications | ZAP-70 Inhibitor |
| Formula | C19H17Cl2N3O4S |
| Molecular Weight | 454.33 |
| SMILES | O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)N(CC2=CC=C(Cl)C=C2)CC3=CC=CO3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.