Fig. 1 · Structure
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Zasocitinib
TYK2 Inhibitor
Zasocitinib (NDI-034858) is a potent inhibitor of TYK2, specifically targeting the JH2 domain with a binding constant Kd of less than 200 pM. This compound exhibits significant biological activity in the modulation of TYK2-driven signaling pathways, making it valuable for research in autoimmune diseases and inflammatory conditions. Its specificity and potency enable detailed exploration of TYK2's role in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2272904-53-5 |
| Applications | TYK2 Inhibitor |
| Formula | C23H24N8O3 |
| Molecular Weight | 460.49 |
| Synonyms | NDI-034858; TAK-279 |
| SMILES | CO[C@H](CC1)[C@@H]1NC(C2=C3N(N=C2)C(NC)=CC(NC4=CC=CN(C5=CC=CC=N5)C4=O)=N3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.