ZCL-278

Catalog No.: A13403

Cdc42 GTPase inhibitor

ZCL-278 Chemical Structure

CAS NO. 587841-73-4

ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
100 mg
$350.00
10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Targets
Cdc42 GTPase
11.4 μM(Kd)
In vitro DMSO 100 mg/mL (170.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.1 mL 85.49 mL 170.97 mL
0.5 mM 3.42 mL 17.1 mL 34.19 mL
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL

*The above data is based on the productmolecular weight 584.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13403
Actions Inhibitor
M. Wt 584.89
Formula C21H19BrClN5O4S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 587841-73-4
Synonyms ZCL278, ZCL 278
SMILES CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C

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