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Publications citing Adooq Products
Chemical Information
| Catalog Num | A13403 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 584.89 |
| Formula | C21H19BrClN5O4S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 587841-73-4 |
| Synonyms | ZCL278, ZCL 278 |
| SMILES code | CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C |
| Chemical Name | 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-?[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]pheny?l]amino]thioxomethyl]acetamide |
Description |
ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects. | ||||||||||
Targets |
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| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (170.97 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.1 mL | 85.49 mL | 170.97mL |
| 0.5 mM | 3.42 mL | 17.1 mL | 34.19 mL |
| 1 mM | 1.71 mL | 8.55 mL | 17.1 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
*The above data is based on the productmolecular weight 584.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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