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ZD06519

Catalog No.: A41008
ADC Cytotoxin/TopI Inhibitor
ZD06519 is a potent ADC cytotoxin and a topoisomerase I inhibitor derived from camptothecin. It exhibits a significant bystander effect, effectively inhibiting various malignancies, including HER2-positive and FRα-overexpressing tumors. By interfering with DNA cleavage, relaxation, and reconnection, ZD06519 induces apoptosis in tumor cells. This compound is ideal for ADC synthesis and applications in cancer research.
ZD06519 2873460-17-2 ADC Cytotoxin/TopI Inhibitor
Grouped product items
Size Price Stock Qty
5mg
$650.00
In stock
10mg
$1,000.00
In stock
25mg
$1,405.00
In stock
50mg
$1,790.00
In stock
100mg
$2,240.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionZD06519 is a potent ADC cytotoxin and a topoisomerase I inhibitor derived from camptothecin. It exhibits a significant bystander effect, effectively inhibiting various malignancies, including HER2-positive and FRα-overexpressing tumors. By interfering with DNA cleavage, relaxation, and reconnection, ZD06519 induces apoptosis in tumor cells. This compound is ideal for ADC synthesis and applications in cancer research.
Product Information
Catalog NumA41008
FormulaC25H24FN3O7
Molecular Weight497.47
CAS Number2873460-17-2
SMILESO=C1N2C(C(C(C2)=C(C3=C4)CNC(OCCO)=O)=NC3=CC(F)=C4C)=CC5=C1COC([C@]5(O)CC)=O
Synonyms7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Antibody-drug Conjugates (ADC) > ADC Payload (ADC Cytotoxin)