Fig. 1 · Structure
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Zelpolib
Pol δ Inhibitor
Zelpolib is a non-competitive inhibitor of DNA polymerase delta (Pol δ), exhibiting robust inhibition of Pol δ activity with a Ki value of 4.3 μM against deoxythymidine triphosphate (dTTP). Zelpolib effectively inhibits cellular DNA replication, demonstrating significant antiproliferative properties. This makes it a valuable tool for research focused on DNA synthesis and cell proliferation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 701932-26-5 |
| Applications | Pol δ Inhibitor |
| Formula | C22H21N3O5S2 |
| Molecular Weight | 471.55 |
| SMILES | O=C(OC)C=1C=C(SC1NC(=S)NNC(=O)CCC2=CC=C(O)C(O)=C2)C=3C=CC=CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.