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Biological Activity
ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.02 mL | 155.11 mL | 310.21 mL |
| 0.5 mM | 6.2 mL | 31.02 mL | 62.04 mL |
| 1 mM | 3.1 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
*The above data is based on the productmolecular weight 322.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19367 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1952264-34-4 |
| Formula | C19H18N2O3 |
| M. Wt | 322.36 |
| Purity | >98% |
| Synonyms | ZEN3219, ZEN 3219 |
| SMILES | O=C(C=CC(C1=C(C)ON=C1C)=C2)N2CC3=CC=C(C4OC4)C=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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