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Zerumin A

Anti-angiogenic Agent

Zerumin A is an anti-angiogenic compound that targets multiple pathways involved in angiogenesis, including KDR/VEGFR2, ANGPT1, ANGPT2, TIE1, and TIE2. It effectively inhibits the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by modulating the VEGF-VEGFR and ANGPT-TIE signaling cascades, with significant inhibition of angiogenesis observed in zebrafish embryos at concentrations of 10-20 μM. Zerumin A is a valuable reagent for research into cancer and angiogenesis-related inflammatory diseases and is naturally derived from the ethanol extract of Alpinia caerulea fruits, seeds, and pericarp.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	176050-48-9
Applications	Anti-angiogenic Agent
Formula	C₂₀H₃₀O₃
Molecular Weight	318.45
SMILES	O=C(O)C/C(C=O)=C\C[C@H]1C(CC[C@@]2([H])C(C)(C)CCC[C@]12C)=C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.