Fig. 1 · Structure
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Zeteletinib hemiadipate
RET Kinase Inhibitor
Zeteletinib hemiadipate is a selective RET kinase inhibitor that acts with nanomolar potency against the RET protein, displaying over 300-fold selectivity for RET over VEGFR2. This compound is effective against wild type RET, as well as RETV804M/L gatekeeper mutants and the prevalent oncogenic mutation M918T. Zeteletinib hemiadipate demonstrates significant antitumor activity, making it a valuable tool for researching RET-related malignancies and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2375837-06-0 |
| Applications | RET Kinase Inhibitor |
| Formula | C25H23F3N4O4.1/2C6H10O4 |
| Molecular Weight | 573.55 |
| Synonyms | BOS-172738 hemiadipate; DS-5010 hemiadipate |
| SMILES | O=C(O)CCCCC(O)=O.O=C(CC1=CC=C(C2=CN=C3C=C(C(OC)=CC3=C2)OC)N=C1)NC4=CC(C(C)(C(F)(F)F)C)=NO4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.