Fig. 1 · Structure
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ZG-2305
FIH Inhibitor
ZG-2305 is a selective inhibitor of factor inhibiting hypoxia-inducible factor (FIH), exhibiting a Ki value of 79.6 nM for FIH. This compound enhances the expression of the EGLN3 gene while simultaneously decreasing cellular triglyceride levels and reducing lipid accumulation. ZG-2305 is a valuable tool for investigating pathways related to obesity and fatty liver disease, enabling researchers to explore potential therapeutic interventions in these metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2962103-54-2 |
| Applications | FIH Inhibitor |
| Formula | C17H11Cl2N3O5 |
| Molecular Weight | 408.19 |
| SMILES | OC(CNC(C1=NC=C(C=C1O)C2=CC(C3=CC(Cl)=CC(Cl)=C3)=NO2)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.