Fig. 1 · Structure
Documents & Downloads
ZG1077
KRAS G12C Inhibitor
ZG1077 is a covalent inhibitor targeting the KRAS G12C mutation. It demonstrates potent inhibitory activity against KRAS-driven cancer cell proliferation, making it a valuable tool for studying non-small cell lung cancer (NSCLC) and other KRAS-related malignancies. This compound facilitates research into therapeutic strategies aimed at inhibiting the KRAS signaling pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2670380-82-0 |
| Applications | KRAS G12C Inhibitor |
| Formula | C33H33F2N5O5S |
| Molecular Weight | 649.71 |
| SMILES | O=S(C)(C1=C(N(C2=C(C(N3[C@H](CN([C@@H](C3)C)C(C=C)=O)C)=N4)C=C(C(C5=C(F)C=CC=C5O)=N2)F)C4=O)C(C6CCC6)=CC=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.