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Zibrofusidic acid

Drug derivative

Zibrofusidic acid is a brominated derivative of Fusidic acid that targets the AcrB protein's hydrophobic groove formed by transmembrane helices 1 and 2. This compound demonstrates significant activity in modulating multidrug efflux pump mechanisms, making it a valuable tool for research in antibiotic resistance and drug delivery studies. Its unique molecular properties enable investigations into efflux-mediated drug interactions and the development of new therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	827603-95-2
Applications	Drug derivative
Formula	C₃₁H₄₇BrO₆
Molecular Weight	595.61
Synonyms	24-Bromofusidic acid; TD-1414
SMILES	C[C@@]([C@](C[C@H]1O)([H])/C2=C(C(O)=O)\CC/C(Br)=C(C)/C)(C[C@@H]2OC(C)=O)[C@]([C@]1([H])[C@]3(CC[C@H]4O)C)(CC[C@@]3([H])[C@@H]4C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.