Fig. 1 · Structure
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Zilebesiran
Angiotensinogen inhibitor
Zilebesiran is a small interfering RNA (siRNA) that selectively inhibits hepatic angiotensinogen expression via RNA interference. This reagent plays a crucial role in the investigation of mild to moderate hypertension, as angiotensinogen is the primary precursor of angiotensin peptides and a significant regulator of systemic blood pressure. Researchers can utilize Zilebesiran to explore therapeutic strategies targeting the renin-angiotensin system in cardiovascular studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2380166-33-4 |
| Applications | Angiotensinogen inhibitor |
| Molecular Weight | 16389.00 |
| Synonyms | AD-85481; ALN-AGT |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.