Fig. 1 · Structure
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Zilganersen sodium
GFAP Inhibitor
Zilganersen sodium is a gapmer antisense oligonucleotide that specifically inhibits glial fibrillary acidic protein (GFAP) synthesis. By targeting the GFAP gene, Zilganersen sodium effectively reduces the accumulation of GFAP associated with pathogenic variants, making it a valuable tool for studying Alexander disease. This compound facilitates research into the mechanisms of glial cell dysfunction and therapeutic approaches in related neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2305355-64-8 |
| Applications | GFAP Inhibitor |
| Formula | C230H301N67O127P19S13Na19 |
| Molecular Weight | 7060.8 (free acid) |
| Synonyms | ION373 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.