ZINC13000658 is an inhibitor of METTL, a family of methyltransferases. This compound demonstrates substantial antiproliferative effects across various cell lines, effectively inducing G1 phase cell cycle arrest and apoptosis in HepG2 (IC50 = 5.632 µM) and SNU-449 (IC50 = 6.184 µM) cells. ZINC13000658's mechanism may involve the inhibition of multiple methyltransferases, including METTL1, METTL3, METTL6, METTL16, and METTL18. This reagent is valuable for investigating various cancer research applications.
ZINC13000658 is an inhibitor of METTL, a family of methyltransferases. This compound demonstrates substantial antiproliferative effects across various cell lines, effectively inducing G1 phase cell cycle arrest and apoptosis in HepG2 (IC50 = 5.632 µM) and SNU-449 (IC50 = 6.184 µM) cells. ZINC13000658's mechanism may involve the inhibition of multiple methyltransferases, including METTL1, METTL3, METTL6, METTL16, and METTL18. This reagent is valuable for investigating various cancer research applications.
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