Fig. 1 · Structure
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ZIP14-IN-1
ZIP14 Inhibitor
ZIP14-IN-1 is a selective and orally active inhibitor of ZIP14 (SLC39A14), targeting the ZIP14-mediated transport of divalent metals such as zinc, iron, manganese, and cadmium. By binding to a specific pocket at the dimer interface of ZIP14, it effectively obstructs the metal transport pathway. This inhibition leads to a reduction in reactive oxygen species (ROS) and lipid peroxidation, mitigating metal-induced cytotoxicity. ZIP14-IN-1 is particularly relevant for research applications focused on cancer cachexia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1048-17-5 |
| Applications | ZIP14 Inhibitor |
| Formula | C21H25N3O |
| Molecular Weight | 335.44 |
| Synonyms | PPTD |
| SMILES | O=C1NCN(C2=CC=CC=C2)C13CCN(CCC4=CC=CC=C4)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.