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ZJH-16

EED Inhibitor

ZJH-16 is a potent and orally active EED inhibitor, demonstrating an IC50 value of 2.72 nM and a Kd of 4.4 nM. This compound effectively inhibits the growth of lymphoma cells while significantly lowering H3K27 trimethylation levels. In preclinical studies, ZJH-16 has shown the ability to impede tumor growth in lymphoma animal models, making it a valuable tool for exploring mechanisms in lymphoma and other cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2877017-58-6
Applications	EED Inhibitor
Formula	C₁₈H₁₄N₆O
Molecular Weight	330.34
SMILES	C12=CC=CC(C3=CN=C(N4C3=NN=C4)NCC5=CC=CO5)=C1NC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.