Fig. 1 · Structure
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ZL-12A probe
ERCC3 Degrader
ZL-12A probe is a selective degrader targeting the ERCC3 helicase within the TFIIH complex. By covalently modifying cysteine residue C342, ZL-12A facilitates the targeted degradation of ERCC3. This compound is valuable for researchers studying DNA repair mechanisms and the functional role of TFIIH in nucleotide excision repair.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3093730-59-4 |
| Applications | ERCC3 Degrader |
| Formula | C24H23N3O2 |
| Molecular Weight | 385.46 |
| SMILES | O=C(N1C[C@H](C2(C1)CN(C2)C(C3=CC=C4NC=CC4=C3)=O)C5=CC=CC=C5)C=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.