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Zn-DPA-maytansinoid conjugate 1

Immune Checkpoint Inhibitor

Zn-DPA-maytansinoid conjugate 1 is a small molecule-based conjugate designed to target immune checkpoints. This compound demonstrates significant anti-tumor activity by inducing prolonged regression of tumor growth and transforming the tumor microenvironment into an "inflamed hot tumor," thereby enhancing immune response. It is an important tool for research applications focused on cancer immunotherapy and checkpoint inhibition strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3034629-04-1
Applications	Immune Checkpoint Inhibitor
Formula	C₁₁₅H₁₄₅ClN₁₈O₃₁S₂Zn₂
Molecular Weight	2505.83
SMILES	[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.C[C@H](C(O[C@@H](CC(N1C)=O)[C@](O2)(C)C2[C@@H](C)[C@@H]3OC(N[C@](O)([C@H](/C=C\C=C(CC4=CC(OC)=C(C1=C4)Cl)/C)OC)C3)=O)=O)N(C(CCSSCCC(NCC5=CC=C(CNC(COCCOCCOCC(N(CCCCOC6=CC(C[N]78CC9=CC=CC=[N]9[Zn+2]7[N](C(NC(CCCCC)=O)=CC=C%10)=C%10C8)=CC(C[N]%11%12CC%13=CC=CC=[N]%13[Zn+2]%11[N](C(NC(CCCCC)=O)=CC=C%14)=C%14C%12)=C6)CC%15=CC=C(C=C%15)C%16=CC=CC=C%16)=O)=O)C=C5)=O)=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.