Fig. 1 · Structure
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Zolunicant
Nicotinic α3β4 Receptor Inhibitor
Zolunicant is a potent inhibitor of the nicotinic α3β4 receptor, demonstrating an IC50 of 0.90 μM. This compound significantly reduces self-administration of various addictive substances, including morphine, methamphetamine, nicotine, and ethanol in rat models, making it a valuable tool for researching substance abuse and addiction therapies. Additionally, Zolunicant exhibits strong leishmanicidal activity against Leishmania amazonensis, highlighting its potential in infectious disease research as well.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 188125-42-0 |
| Applications | Nicotinic α3β4 Receptor Inhibitor |
| Formula | C22H28N2O3 |
| Molecular Weight | 368.47 |
| Synonyms | MM-110; (±)-18-Methoxycoronaridine |
| SMILES | COC([C@]12[C@@]3([H])[N@@](CCC4=C2NC5=CC=CC=C54)C[C@@](C[C@@H]3CCOC)([H])C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.