Fig. 1 · Structure
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Zotepine
Antipsychotic Agent
Zotepine is an antipsychotic agent that acts as a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with dissociation constants (Kds) of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. This compound demonstrates significant antidepressant and anxiolytic effects in vivo, making it valuable for research in neuropharmacology and the treatment of psychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 26615-21-4 |
| Applications | Antipsychotic Agent |
| Formula | C18H18ClNOS |
| Molecular Weight | 331.86 |
| SMILES | ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.