ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of the TAF1 protein. This compound effectively activates p53, leading to apoptosis in acute myeloid leukemia (AML) cells. In vivo studies have demonstrated its antitumor efficacy in AML tumor xenograft mouse models, making ZS3-046 a valuable tool for researching targeted degradation strategies in cancer therapy.
ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of the TAF1 protein. This compound effectively activates p53, leading to apoptosis in acute myeloid leukemia (AML) cells. In vivo studies have demonstrated its antitumor efficacy in AML tumor xenograft mouse models, making ZS3-046 a valuable tool for researching targeted degradation strategies in cancer therapy.
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