Fig. 1 · Structure
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ZW-1226
MRP1 Inhibitor
ZW-1226 is a selective inhibitor of multidrug resistance protein 1 (MRP1), effectively decreasing the uptake activity of MRP1 vesicles by 65% at a concentration of 5 μM. This compound exhibits GSH-dependent inhibition and demonstrates notable selectivity for MRP1 over other key ABC transporters, such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), MRP2, and MRP3. ZW-1226 is valuable in research applications focused on drug resistance and transport mechanisms in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2351940-23-1 |
| Applications | MRP1 Inhibitor |
| Formula | C25H16N4O3 |
| Molecular Weight | 420.42 |
| SMILES | O=C(N=C1C2=CC3=C(C=C(C#N)C=C3)N1C4=CC=C(OCC5=CC=CC=C5)C=C4)NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.