Fig. 1 · Structure
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ZY-444
Pyruvate Carboxylase Inhibitor
ZY-444 is a potent inhibitor of pyruvate carboxylase (PC), demonstrating significant anti-cancer activity. By blocking the nuclear translocation of β-catenin, ZY-444 disrupts the Wnt/β-catenin/Snail signaling pathway, leading to reduced proliferation, migration, and invasion of cancer cells, while also inducing apoptosis. This reagent is particularly relevant for research in breast cancer, non-small cell lung cancer, prostate cancer, and iodine-refractory thyroid cancer, with demonstrated efficacy in tumor models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1802650-31-2 |
| Applications | Pyruvate Carboxylase Inhibitor |
| Formula | C26H28N4OS |
| Molecular Weight | 444.59 |
| SMILES | CC(C)CNC1=NC=CC(NCC2=CC=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)S2)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.