Fig. 1 · Structure

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A-484954

Cat. No. A13447 CAS 142557-61-7

eEF2K (CAMKIII) inhibitor

A-484954 is a potent, selective inhibitor of eukaryotic longation factor-2 kinase (eEF2K).

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
MDA-MB-231 IC50 > 100 μM Antiproliferative activity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay [PMID: 29202403]
MDA-MB-436 IC50 > 100 μM Antiproliferative activity against human MDA-MB-436 cells assessed as decrease in cell viability after 24 hrs by MTT assay [PMID: 29202403]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 142557-61-7
Applications eEF2K (CAMKIII) inhibitor
Formula C13H15N5O3
Molecular Weight 289.2899
SMILES
CCn1c(=O)c2cc(c(nc2n(c1=O)C3CC3)N)C(=O)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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