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Alogliptin

Name: Alogliptin
Brand: Adooq Bioscience
SKU: A13571
Availability: InStock

Cat. No. A13571 CAS 850649-61-5

DPP-4 inhibitor

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

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Biological Activity

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

Target & Activity

Target	Activity	Value
DPP-4		<10 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
Caco-2	IC50	24 nM	Inhibition of DPP4 in human Caco2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate after 1 hr by fluorescence assay	[PMID: 23623674]
Sf9	IC50	> 100 μM	Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay	[PMID: 30642693]
Sf9	IC50	> 100 μM	Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay	[PMID: 30642693]
Sf9	IC50	2.7 nM	Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay	[PMID: 30642693]
Sf9	IC50	4.46 nM	Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interval for 20 mins by fluorometic method	[PMID: 31336309]
U-87MG ATCC	IC50	1470 μM	Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assay	[PMID: 32527554]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	850649-61-5
Applications	DPP-4 inhibitor
Formula	C₁₈H₂₁N₅O₂
Molecular Weight	339.397
Synonyms	SYR-322; Axagliptin hydrate
SMILES	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	59 mg/mL (173.84 mM)
Water	16 mg/mL (47.14 mM)
Ethanol	59 mg/mL (173.84 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.