DPP-4

Cat. No.

A11109

CAS No.

361442-04-8

Saxagliptin (BMS-477118)

Synonyms: BMS-477118; Onglyza

Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM.

Cat. No.

A14377

CAS No.

486460-32-6

Sitagliptin

Synonyms: MK-0431

Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.

Cat. No.

A11224

CAS No.

668270-12-0

Linagliptin (BI-1356)

Synonyms: BI-1356; Tradjenta; Trajenta

Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

Cat. No.

A12528

CAS No.

274901-16-5

Vildagliptin

Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor.

Cat. No.

A14293

CAS No.

865759-25-7

Trelagliptin

Synonyms: SYR-472

Trelagliptin is a highly selective, long-acting DPP-4 inhibitor.

Cat. No.

A21285

CAS No.

911637-19-9

Gemigliptin

Gemigliptin is a highly selective dipeptidyl peptidase 4 (DPP4) inhibitor with a KD of 7.25 nM.

Cat. No.

A10848

CAS No.

654671-77-9

Sitagliptin phosphate monohydrate

Synonyms: Januvia; MK-0431

Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.

Cat. No.

A13026

CAS No.

31314-39-3

Prodipine hydrochloride

Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.

Cat. No.

A13310

CAS No.

1226781-44-7

MK-3102

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).

Cat. No.

A13311

CAS No.

850649-62-6

Alogliptin Benzoate

Synonyms: SYR-322; Nesina

Alogliptin Benzoate is a dipeptidyl-peptidase-4 (DPP 4) inhibitor

Cat. No.

A13312

CAS No.

1029877-94-8

Trelagliptin Succinate (SYR-472)

Synonyms: SYR472; SYR 111472

Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).

Cat. No.

A13529

CAS No.

739366-20-2

Anagliptin

Synonyms: SK-0403

Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.

Cat. No.

A13571

CAS No.

850649-61-5

Alogliptin

Synonyms: SYR-322; Axagliptin hydrate

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of

Cat. No.

A13771

CAS No.

136259-18-2

DPP-IV-IN-2

DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively.

Cat. No.

A14079

CAS No.

149682-77-9

Talabostat

Synonyms: Val-boroPro; PT100

Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM).

Cat. No.

A14080

CAS No.

150080-09-4

Talabostat mesylate

Talabostat mesylate is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.

Cat. No.

A15258

CAS No.

906093-29-6

Teneligliptin hydrobromide

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Cat. No.

A15298

CAS No.

866396-34-1

DPPI 1c hydrochloride

Synonyms: Dipeptidylpeptidase IV Inhibitor III

DPPI 1c hydrochloride is a dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of CD26 (DPP 4), with an IC50 = 106 nM and little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM.

Cat. No.

A15309

CAS No.

1017682-65-3

PK 44 phosphate

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM.

Cat. No.

A15320

CAS No.

247016-69-9

NVP DPP 728 dihydrochloride

NVP DPP 728 dihydrochloride is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.

Cat. No.

A15505

CAS No.

760937-92-6

Teneligliptin

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Cat. No.

A16047

CAS No.

697797-51-6

UAMC 00039 dihydrochloride

UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively).

Cat. No.

A16694

CAS No.

945667-22-1

Saxagliptin hydrate

Synonyms: BMS-477118 hydrate

Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.

Cat. No.

A17095

CAS No.

1802148-05-5

AZD7986

Synonyms: INS 1007

AZD7986, also known as INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing.

Cat. No.

A18709

CAS No.

847928-32-9

1G244

1G244 is a novel potent and selective DPP8/9 inhibitor.