AMG-47a

Catalog No.: A13167
Lck inhibitor
AMG-47a is an orally bioavailable potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED50 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.
Grouped product items
Product Name Price Stock Qty
AMG-47a 5mg
$120.00
In stock
AMG-47a 10mg
$200.00
In stock
AMG-47a 25mg
$450.00
In stock
AMG-47a 50mg
$780.00
In stock
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Biological Activity
Discription AMG-47a is an orally bioavailable potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED50 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.
Product Information
Catalog Num A13167
Formula C29H28F3N5O2
Molecular Weight 535.56
CAS Number 882663-88-9
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=CN=C(N=C4C=C3)NCCN5CCOCC5
Synonyms AMG47a, Geneticin
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 2 mg/mL (3.73 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.67 mL 93.36 mL 186.72 mL
0.5 mM 3.73 mL 18.67 mL 37.34 mL
1 mM 1.87 mL 9.34 mL 18.67 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
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