Target & Activity
| Target | Activity | Value |
|---|---|---|
| S1PR1 | EC50 | 0.39 nM |
| S1PR5 | EC50 | 0.98 nM |
| S1PR4 | EC50 | 750 nM |
| S1PR3 | EC50 | >1000 nM |
| S1PR2 | EC50 | >10000 nM |
Fig. 1 · Structure
Documents & Downloads
BAF312 (Siponimod)
Cat. No.
A12906
CAS
1230487-00-9
S1PR1/S1PR5 inhibitor
BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 and S1P5.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1230487-00-9 |
| Applications | S1PR1/S1PR5 inhibitor |
| Formula | C29H35F3N2O3 |
| Molecular Weight | 516.6 |
| Synonyms | Siponimod |
| SMILES | CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | Warmed: 99 mg/mL (191.63 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 44 mg/mL (85.17 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.