Bafetinib (INNO-406)

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Bcr-Abl inhibitor

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Catalog No. A10119

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Bafetinib 5mg A10119-5

Regular Price: $75.00

Special Price: $63.75

Bafetinib 10mg A10119-10

Regular Price: $130.00

Special Price: $110.50

Bafetinib 50mg A10119-50

Regular Price: $390.00

Special Price: $331.50

Bafetinib 100mg A10119-100

Regular Price: $480.00

Special Price: $408.00

Bafetinib (INNO-406) 10mM * 1mL in DMSO A10119-10mM-D

Regular Price: $174.00

Special Price: $147.90

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.

Bafetinib (INNO-406)

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Chemical Information

Catalog Num A10119
Actions Inhibitor
M. Wt 576.6
Formula C30H31F3N8O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 859212-16-1
Synonyms NS-187
SMILES code CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[[email protected]@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5
Chemical Name N-[3-([5,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide

Biological Activity

Description
Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.
Targets
Abl (Cell-free assay) Lyn (Cell-free assay)
5.8 nM19 nM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (173.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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