Bcr-Abl

Cat. No.

A10290

CAS No.

302962-49-8

Dasatinib (BMS-354825)

Synonyms: Sprycel; BMS-354825

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.

Cat. No.

A10080

CAS No.

943319-70-8

Ponatinib (AP24534)

Synonyms: AP24534

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.

Cat. No.

A10259

CAS No.

152459-95-5

Imatinib (Gleevec)

Synonyms: STI571; Glivec; Gleevec

Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.

Cat. No.

A10119

CAS No.

859212-16-1

Bafetinib (INNO-406)

Synonyms: NS-187; INNO-406

Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.

Cat. No.

A10108

CAS No.

379231-04-6

Saracatinib (AZD0530)

Synonyms: AZD0530

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.

Cat. No.

A10468

CAS No.

220127-57-1

Imatinib Mesylate

Synonyms: Gleevec; Glivec; CGP-57148B; STI-571

Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.

Cat. No.

A10644

CAS No.

641571-10-0

Nilotinib (AMN-107)

Synonyms: AMN-107

Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.

Cat. No.

A10661

CAS No.

940310-85-0

NVP-BHG712

Synonyms: BHG712

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.

Cat. No.

A10095

CAS No.

896466-04-9

AT9283

AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.

Cat. No.

A10715

CAS No.

827318-97-8

Danusertib (PHA-739358)

Synonyms: PHA-739358

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2

Cat. No.

A10988

CAS No.

856243-80-6

WP1130 (Degrasyn)

Synonyms: Degrasyn

WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.

Cat. No.

A11200

CAS No.

1020172-07-9

Rebastinib (DCC-2036)

Synonyms: DCC2036

DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

Cat. No.

A15186

CAS No.

923288-90-8

Nilotinib monohydrochloride monohydrate

Synonyms: AMN-107; Tasigna

Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.

Cat. No.

A16320

CAS No.

863127-77-9

Dasatinib Monohydrate

Synonyms: BMS354825

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of

Cat. No.

A10508

CAS No.

1000669-72-6

KW-2449

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.

Cat. No.

A11207

CAS No.

1092788-83-4

PP121

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).

Cat. No.

A11262

CAS No.

871357-89-0

Cenisertib

Synonyms: AS-703569; R-763

Cenisertib (AS-703569) is a multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3.

Cat. No.

A11379

CAS No.

484049-04-9

DPH

DPH is a c-ABL activitor.

Cat. No.

A11439

CAS No.

778270-11-4

GNF 2

GNF 2 is a Bcr-abl inhibitor that inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells.

Cat. No.

A12421

CAS No.

2081093-21-0

CHMFL-ABL/KIT-155

Synonyms: CHMFL-ABL-KIT-155

CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor.

Cat. No.

A12496

CAS No.

188260-50-6

BCR-ABL-IN-1

BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.

Cat. No.

A13029

CAS No.

926037-48-1

Radotinib (IY-5511)

Synonyms: IY-5511

Radotinib is a novel and selective Bcl-Abl tyrosine kinase inhibitor

Cat. No.

A13069

CAS No.

898280-07-4

XL-228

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.

Cat. No.

A13120

CAS No.

260415-63-2

PD173955

PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.

Cat. No.

A13182

CAS No.

2304344-56-5

CHMFL-ABL-039

CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor with the IC50s of 7.9 nM and 27.9 nM, respectively. CHMFL-ABL-039 is used in the research of chronic myeloid leukemia.