Bardoxolone methyl (RTA 402)

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IκB/IKK inhibitor

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Catalog No. A11323

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Bardoxolone methyl 25mg A11323-25

Regular Price: $90.00

Special Price: $72.00

Bardoxolone methyl 50mg A11323-50

Regular Price: $160.00

Special Price: $128.00

Bardoxolone methyl 100mg A11323-100

Regular Price: $280.00

Special Price: $224.00

Bardoxolone methyl 200mg A11323-200

Regular Price: $450.00

Special Price: $360.00

Bardoxolone methyl (RTA 402) 10mM * 1mL in DMSO A11323-10mM-D

Regular Price: $77.00

Special Price: $61.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

Bardoxolone methyl (RTA 402)

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Chemical Information

Catalog Num A11323
Actions Inhibitor
M. Wt 505.7
Formula C32H43NO4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 218600-53-4
Synonyms NSC 713200, CDDO-methyl ester
SMILES code C[C@@]12CC[C@]3(CCC(C[[email protected]]3[[email protected]]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
Chemical Name Methyl 2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate

Biological Activity

Description
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
Targets
IKK (Cell-free assay)

Solubility

Solubility (25°C) * In vitro DMSO 21 mg/mL (41.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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