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dual antagonist of TP/DP2
In Stock
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| Target | Activity | Value |
|---|---|---|
| hTP | IC50 | 14 nM |
| hDP2 | IC50 | 113 nM |
| hDP2 | IC50 | 33.4 μM |
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HEK293 | IC50 | 77 nM | Displacement of [3H]PGD2 from human CRTh2 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay | [PMID: 21355602] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 116649-85-5 |
| Applications | dual antagonist of TP/DP2 |
| Formula | C21H21FN2O4S |
| Molecular Weight | 416.5 |
| Synonyms | Ramatroban |
| SMILES | C1CC2=C(C[C@@H]1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 76 mg/mL (182.48 mM) |
| Water | Insoluble |
| Ethanol | 76 mg/mL |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
