BEZ235 (NVP-BEZ235, Dactolisib)

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PI3K/mTOR Inhibitor

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Catalog No. A10133

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BEZ235 25mg A10133-25

Regular Price: $30.00

Special Price: $25.50

BEZ235 50mg A10133-50

Regular Price: $50.00

Special Price: $42.50

BEZ235 100mg A10133-100

Regular Price: $80.00

Special Price: $68.00

BEZ235 200mg A10133-200

Regular Price: $140.00

Special Price: $119.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.

BEZ235 (NVP-BEZ235, Dactolisib)

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Chemical Information

Catalog Num A10133
Actions Inhibitor
M. Wt 469.6
Formula C30H23N5O
Solubility DMSO>7mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 2 years
CAS No. 915019-65-7
Synonyms N/A
SMILES code CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Chemical Name 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile

Biological Activity

Description
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
Targets
Target Value
p110αIC50: 4nM
p110γIC50: 5nM
mTOR(p70S6K)IC50: 6nM
p110δIC50: 7nM
ATRIC50: 21nM
p110βIC50: 75nM
EGFR/ErbB1IC50: >8.5μM
VEGFR1/FLT1IC50: >10μM
FLT3IC50: >10μM
IGF-1RIC50: >10μM
EphB4IC50: >10μM
RETIC50: >10μM
Tie-2IC50: >10μM
c-MetIC50: >10μM
FGFR(K650E)IC50: >10μM
FAKIC50: >10μM
JAK2IC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
PKAIC50: >10μM
Akt1/PKBαIC50: >10μM
PDK-1IC50: >10μM
B-Raf(V599E)IC50: >10μM
CDK1IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 0.01 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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